ANIMAL MEDICINE

Lvermectin 1% ivermectin is a novel broad-spectrum, efficient, and low toxicity antibiotic class antiparasitic drug, which has a good repellent effect on both in vivo and in vitro parasites, especially nematodes and arthropods. But it is ineffective for tapeworms, flukes, and protozoa. The insecticidal effect of macrolide antibiotics on nematodes and arthropods is to increase the inhibitory neurotransmitters of the parasite body γ- The release of aminobutyric acid (GABA) and the opening of glutamate controlled Cl ion channels enhance the permeability of the nerve membrane to Cl, thereby blocking the transmission of neural signals, ultimately leading to nerve paralysis and loss of muscle cell contraction ability, resulting in parasite death.